2021-02-10

Om Helena väljs in i styrelsen är jag övertygad om att hon kommer vara en värdefull tillgång i det fortsatta ledningsarbetet, säger A1M Pharmas styrelseordförande Martin Austin. – Jag vill passa på att tacka Bo Åkerström och Stefan Hansson för deras engagemang som styrelseledamöter i bolaget sedan grundandet 2008.

Studierna bedrivs i samarbete mellan professor Åkerström och A1M Pharma. Finally, A1M bound to purified collagen I (K(d) = 0.96×10(-6) M) and could inhibit and repair the destruction of collagen fibrils by heme and reactive oxygen species. The results suggest that A1M may have a physiological role in protection of skin cells and matrix against oxidative damage following bleeding. The cysteine 34 residue of A1M/1-microglobulin is essential for protection of irradiated cell cultures and reduction of carbonyl groups. Rutardottir, Sigurbjörg; Nilsson, E J C; Pallon, Jan; Gram, Magnus; Åkerström, Bo Published in: Free Radical Research DOI: 10.3109/10715762.2013.801555 2013 Link to publication Citation for published Bo Åkerström har ägnat hela sitt yrkesliv åt att förstå och beskriva proteinet A1M och de senaste tio åren har vi studerat det i laboratoriet som möjligt läkemedel. De kliniska studierna blir avgörande. Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates.

Bo åkerström a1m

α1-microglobulin (A1M) is a small protein present in vertebrates including humans. It has several physiologically relevant properties, including binding of heme and radicals as well as enzymatic reduction, that are used in the protection of cells and tissue. Research has revealed that A1M can ameliorate heme and ROS-induced injuries in cell cultures, organs, explants and animal models. Bo Åkerström has spent his entire professional life on understanding and describing the properties of the A1M protein and, in the last ten years, we have been studying it in the laboratory as a Expression of the A1M gene in skin and in primary keratinocyte cultures obtained from skin was shown by real time PCR and radioimmunoassay (RIA) (Fig 1C, D and E, Table 1).The expression was significantly up-regulated after incubation of the skin explants or keratinocyte cultures with heme or hydroxyl radical-producing Fenton reaction-mixture for 20 hours.

Ten years ago Bo Åkerström and his research group demonstrated that A1M has the ability to bind the free radicals and the toxic heme molecules and convert them into harmless substances.

Söndagsintervjun: Bo Åkerström & Martin Austin, A1M Pharma. 18 december, 2016. Tidigare under hösten meddelade A1M Pharma att man valt njurskydd i samband med målsökande strålbehandling av tumörer, s.k. PRRT-behandling, som första inriktning inom … A1M can be internalized by cells, localized to the mitochondria and protect mitochondrial function.

A1M is a potential kidney protector in 177Lu-octreotate treatment of neuroendocrine tumours Charlotte Andersson, Emman Shubbar, Bo Åkerström

The cysteine 34 residue of A1M/1-microglobulin is essential for protection of irradiated cell cultures and reduction of carbonyl groups. Rutardottir, Sigurbjörg; Nilsson, E J C; Pallon, Jan; Gram, Magnus; Åkerström, Bo Published in: Free Radical Research DOI: 10.3109/10715762.2013.801555 2013 Link to publication Citation for published Together with his colleague, Bo Åkerström, professor of infection medicine, Stefan Hansson started the studies on A1M several years ago and observed that A1M stopped the leakage of protein in the kidneys. They also saw that the placenta was repaired and that the destroyed structures in the cells’ smallest components were restored.

Stefan Hansson har tillsammans med professor Bo Åkerström lyckats identifiera ett protein, alfa-1-microglobulin (A1M), som kan vara grunden o A1M Pharma utvecklar biologisk läkemedelskandidat som bygger på kroppseget När Bo Åkerström, en av bolagets grundare, 1974 började. Historien om läkemedelsbolaget A1M Pharma startade redan 1974 när Bo Åkerström, idag professor vid Lunds universitet, började studera det kroppsegna Forskningsbolaget A1M Pharma har gjort ett omtag på både finansiell Professor Bo Åkerström har forskat på det kroppsegna proteinet A1M The aims of this project are to 1) investigate protective mechanisms of A1M, 2) develop a large-scale purification process of A1M for in vivo studies, and 3) Koordinerande organisation: Lunds universitet; Projektledare: Bo Åkerström. fungerar ihop är något professor Bo Åkerström ibland funderar över. att studera proteinet A1M som finns hos alla däggdjur och är en viktig Fredrik Olsson är genom bolaget Private placement sprl största ägare i A1M i Lund grundat av forskarna Stefan Hansson, Bo Åkerström och Magnus Gram A1M Pharma arbetar nu för fullt med ett test som på ett tidigt stadium kan Då inledde han och Bo Åkerström ett samarbete med Stefan Bakom förslaget står större aktieägare i A1M Pharma.
Twh na mwh

Rutardottir, Sigurbjörg; Nilsson, E J C; Pallon, Jan; Gram, Magnus; Åkerström, Bo Published in: Free Radical Research DOI: 10.3109/10715762.2013.801555 2013 Link to publication Citation for published Bo Åkerström har ägnat hela sitt yrkesliv åt att förstå och beskriva proteinet A1M och de senaste tio åren har vi studerat det i laboratoriet som möjligt läkemedel. De kliniska studierna blir avgörande. Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates. The protein was discovered 40 years ago and its physiological role remained unknown for a long time.

1. and radical scavenger that may participate in the Together with his colleague, Bo Åkerström, professor of infection medicine, Stefan Hansson started the studies on A1M several years ago and observed that A1M stopped the leakage of protein in the kidneys. They also saw that the placenta was repaired and that the destroyed structures in the cells’ smallest components were restored.
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Expression of the A1M gene in skin and in primary keratinocyte cultures obtained from skin was shown by real time PCR and radioimmunoassay (RIA) (Fig 1C, D and E, Table 1).The expression was significantly up-regulated after incubation of the skin explants or keratinocyte cultures with heme or hydroxyl radical-producing Fenton reaction-mixture for 20 hours.

1. Section for The human antioxidant α1-microglobulin (A1M) is a plasma and tissue protein. 16 dec 2013 Bo Åkerström och Stefan Hansson.

Andra halvan står forskarkollegan Bo Åkerström för. Tillsammans har kollegorna startat läkemedelsbolaget A1M Pharma för att kunna

Studierna bedrivs i samarbete mellan professor Åkerström och A1M Pharma. Aleksenko, Larysa LU; Åkerström, Bo LU; Hansson, Eva LU; Erlandsson, Lena LU and Hansson, Stefan R. LU In Scientific Reports 10 (1).

Board Members (4). Name Bo Åkerström. Representing A1M Pharma. 30 mar 2017 Bo Åkerström, Styrelseledamot.